Before Owensboro, Kentucky was settled by European Americans, it was inhabited by various indigenous peoples, including the Cherokee and Chickasaw tribes. The area was initially explored by French and Spanish explorers in the 18th century. In 1797, William Smeathers founded Owensborough, which was later shortened to Owensboro.
After Owensboro’s founding, it quickly grew into a significant river port town along the Ohio River. The town became a hub for trade, particularly in tobacco, which was a major crop in the region. The steamboat era further bolstered Owensboro’s importance as a transportation center.
In the 20th century, Owensboro diversified its economy, expanding into manufacturing and healthcare. Today, Owensboro is known for its healthcare services, including Owensboro Health, one of the largest hospital systems in the region. The city also hosts various cultural events and festivals, such as the International Bluegrass Music Museum and the International Bar-B-Q Festival, which celebrate its rich cultural heritage. Additionally, Owensboro is home to several higher education institutions, contributing to its vibrant and growing community.